Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors

We identified clinical isolates with phenotypic resistance to nevirapine (NVP) in the absence of known nonnucleoside reverse transcriptase inhibitor (NNRTI) mutations. This resistance is caused by N348I, a mutation at the connection subdomain of human immunodeficiency virus type 1 (HIV-1) reverse tr...

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Auteurs principaux: Hachiya, Atsuko, Kodama, Eiichi N., Sarafianos, Stefan G., Schuckmann, Matthew M., Sakagami, Yasuko, Matsuoka, Masao, Takiguchi, Masafumi, Gatanaga, Hiroyuki, Oka, Shinichi
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2008
Sujets:
Vaccines and Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2268505/
https://ncbi.nlm.nih.gov/pubmed/18216099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01154-07
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