HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors

Polymorphisms have poorly understood effects on drug susceptibility and may affect the outcome of HIV treatment. We have discovered that an HIV-1 reverse transcriptase (RT) polymorphism (RT(172K)) is present in clinical samples and in widely used laboratory strains (BH10), and it profoundly affects...

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Hauptverfasser: Hachiya, Atsuko, Marchand, Bruno, Kirby, Karen A., Michailidis, Eleftherios, Tu, Xiongying, Palczewski, Krzysztof, Ong, Yee Tsuey, Li, Zhe, Griffin, Daniel T., Schuckmann, Matthew M., Tanuma, Junko, Oka, Shinichi, Singh, Kamalendra, Kodama, Eiichi N., Sarafianos, Stefan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Microbiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436141/
https://ncbi.nlm.nih.gov/pubmed/22761416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351551
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