HIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT Inhibitors

Polymorphisms have poorly understood effects on drug susceptibility and may affect the outcome of HIV treatment. We have discovered that an HIV-1 reverse transcriptase (RT) polymorphism (RT(172K)) is present in clinical samples and in widely used laboratory strains (BH10), and it profoundly affects...

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Detalhes bibliográficos
Main Authors: Hachiya, Atsuko, Marchand, Bruno, Kirby, Karen A., Michailidis, Eleftherios, Tu, Xiongying, Palczewski, Krzysztof, Ong, Yee Tsuey, Li, Zhe, Griffin, Daniel T., Schuckmann, Matthew M., Tanuma, Junko, Oka, Shinichi, Singh, Kamalendra, Kodama, Eiichi N., Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436141/
https://ncbi.nlm.nih.gov/pubmed/22761416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.351551
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