Effects of Substitutions at the 4′ and 2 Positions on the Bioactivity of 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine

Nucleos(t)ide reverse transcriptase inhibitors (NRTIs) form the backbone of most anti-HIV therapies. We have shown that 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a highly effective NRTI; however, the reasons for the potent antiviral activity of EFdA are not well understood. Here, we use a comb...

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Detalhes bibliográficos
Main Authors: Kirby, Karen A., Michailidis, Eleftherios, Fetterly, Tracy L., Steinbach, Musetta A., Singh, Kamalendra, Marchand, Bruno, Leslie, Maxwell D., Hagedorn, Ariel N., Kodama, Eiichi N., Marquez, Victor E., Hughes, Stephen H., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837839/
https://ncbi.nlm.nih.gov/pubmed/24100493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01703-13
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