4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a nucleoside analog that, unlike approved anti-human immunodeficiency virus type 1 (HIV-1) nucleoside reverse transcriptase inhibitors, has a 3′-OH and exhibits remarkable potency against wild-type and drug-resistant HIVs. EFdA triphosphate (EFdA-TP) i...

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Autores principales: Michailidis, Eleftherios, Huber, Andrew D., Ryan, Emily M., Ong, Yee T., Leslie, Maxwell D., Matzek, Kayla B., Singh, Kamalendra, Marchand, Bruno, Hagedorn, Ariel N., Kirby, Karen A., Rohan, Lisa C., Kodama, Eiichi N., Mitsuya, Hiroaki, Parniak, Michael A., Sarafianos, Stefan G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148878/
https://ncbi.nlm.nih.gov/pubmed/24970894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562694
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