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Cooperative Signaling via Transcription Factors NF-κB and AP1/c-Fos Mediates Endothelial Cell STIM1 Expression and Hyperpermeability in Response to Endotoxin

Stromal interacting molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE). Here we show that STIM1 expression in endothelial cells (ECs) is increased during sepsis and, therefore, contributes to hyperpermeability. LPS induced STIM1 mRNA and protein expression in human and mouse lung ECs. T...

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Bibliografske podrobnosti
Main Authors: DebRoy, Auditi, Vogel, Stephen M., Soni, Dheeraj, Sundivakkam, Premanand C., Malik, Asrar B., Tiruppathi, Chinnaswamy
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148850/
https://ncbi.nlm.nih.gov/pubmed/25016017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570051
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