Ca(2+) influx via TRPC channels induces NF-κB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells

NF-κB signaling is known to induce the expression of antiapoptotic and proinflammatory genes in endothelial cells (ECs). We have shown recently that Ca(2+) influx through canonical transient receptor potential (TRPC) channels activates NF-κB in ECs. Here we show that Ca(2+) influx signal prevents th...

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Detalhes bibliográficos
Main Authors: Thippegowda, Prabhakar B., Singh, Vandana, Sundivakkam, Premanand C., Xue, Jiaping, Malik, Asrar B., Tiruppathi, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838565/
https://ncbi.nlm.nih.gov/pubmed/20032510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00456.2009
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