Store-operated Ca(2+) Entry (SOCE) Induced by Protease-activated Receptor-1 Mediates STIM1 Protein Phosphorylation to Inhibit SOCE in Endothelial Cells through AMP-activated Protein Kinase and p38β Mitogen-activated Protein Kinase

The Ca(2+) sensor STIM1 is crucial for activation of store-operated Ca(2+) entry (SOCE) through transient receptor potential canonical and Orai channels. STIM1 phosphorylation serves as an “off switch” for SOCE. However, the signaling pathway for STIM1 phosphorylation is unknown. Here, we show that...

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Detalhes bibliográficos
Main Authors: Sundivakkam, Premanand C., Natarajan, Viswanathan, Malik, Asrar B., Tiruppathi, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675634/
https://ncbi.nlm.nih.gov/pubmed/23625915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.411272
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