The Ca(2+) Sensor Stromal Interaction Molecule 1 (STIM1) Is Necessary and Sufficient for the Store-Operated Ca(2+) Entry Function of Transient Receptor Potential Canonical (TRPC) 1 and 4 Channels in Endothelial Cells

We addressed the requirement for stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+)-sensor, and Orai1, a Ca(2+) selective channel, in regulating Ca(2+) entry through the store-operated channels mouse transient receptor potential canonical (TRPC) 4 or human TRPC1. Studies w...

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Main Authors: Sundivakkam, Premanand C., Freichel, Marc, Singh, Vandana, Yuan, Joseph P., Vogel, Stephen M., Flockerzi, Veit, Malik, Asrar B., Tiruppathi, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310414/
https://ncbi.nlm.nih.gov/pubmed/22210847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.074658
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