Ca(2+) Entry via TRPC Channels Is Necessary for Thrombin-induced NF-κB Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase Cδ

The transient receptor potential canonical (TRPC) family channels are proposed to be essential for store-operated Ca(2+) entry in endothelial cells. Ca(2+) signaling is involved in NF-κB activation, but the role of store-operated Ca(2+) entry is unclear. Here we show that thrombin-induced Ca(2+) ent...

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Detalhes bibliográficos
Main Authors: Bair, Angela M., Thippegowda, Prabhakar B., Freichel, Marc, Cheng, Ni, Ye, Richard D., Vogel, Stephen M., Yu, Yanni, Flockerzi, Veit, Malik, Asrar B., Tiruppathi, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610508/
https://ncbi.nlm.nih.gov/pubmed/18990707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803984200
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