Cooperative Signaling via Transcription Factors NF-κB and AP1/c-Fos Mediates Endothelial Cell STIM1 Expression and Hyperpermeability in Response to Endotoxin

Stromal interacting molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE). Here we show that STIM1 expression in endothelial cells (ECs) is increased during sepsis and, therefore, contributes to hyperpermeability. LPS induced STIM1 mRNA and protein expression in human and mouse lung ECs. T...

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Detalhes bibliográficos
Main Authors: DebRoy, Auditi, Vogel, Stephen M., Soni, Dheeraj, Sundivakkam, Premanand C., Malik, Asrar B., Tiruppathi, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148850/
https://ncbi.nlm.nih.gov/pubmed/25016017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570051
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