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Cooperative Signaling via Transcription Factors NF-κB and AP1/c-Fos Mediates Endothelial Cell STIM1 Expression and Hyperpermeability in Response to Endotoxin

Stromal interacting molecule 1 (STIM1) regulates store-operated Ca(2+) entry (SOCE). Here we show that STIM1 expression in endothelial cells (ECs) is increased during sepsis and, therefore, contributes to hyperpermeability. LPS induced STIM1 mRNA and protein expression in human and mouse lung ECs. T...

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Autori principali: DebRoy, Auditi, Vogel, Stephen M., Soni, Dheeraj, Sundivakkam, Premanand C., Malik, Asrar B., Tiruppathi, Chinnaswamy
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148850/
https://ncbi.nlm.nih.gov/pubmed/25016017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.570051
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