NF-κB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-κB site in the ICAM-1 gene

Activation of NF-κB is essential for protease-activated receptor-1 (PAR-1)-mediated ICAM-1 expression in endothelial cells. Here we show that PAR-1 activation induces binding of both p65/RelA and NFATc1 to the NF-κB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in e...

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Detalhes bibliográficos
Main Authors: Xue, Jiaping, Thippegowda, Prabhakar B., Hu, Guochang, Bachmaier, Kurt, Christman, John W., Malik, Asrar B., Tiruppathi, Chinnaswamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696150/
https://ncbi.nlm.nih.gov/pubmed/19351910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00012.2009
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