Wild-type macrophages reverse disease in heme oxygenase 1-deficient mice

Loss-of-function mutation in the heme oxygenase 1 (Hmox1) gene causes a rare and lethal disease in children, characterized by severe anemia and intravascular hemolysis, with damage to endothelia and kidneys. Previously, we found that macrophages engaged in recycling of red cells were depleted from t...

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Bibliografiske detaljer
Main Authors: Kovtunovych, Gennadiy, Ghosh, Manik C., Ollivierre, Wade, Weitzel, R. Patrick, Eckhaus, Michael A., Tisdale, John F., Yachie, Akihiro, Rouault, Tracey A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4148774/
https://ncbi.nlm.nih.gov/pubmed/24963040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-554162
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