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Dysfunction of the heme recycling system in heme oxygenase 1–deficient mice: effects on macrophage viability and tissue iron distribution
To better understand the tissue iron overload and anemia previously reported in a human patient and mice that lack heme oxygenase-1 (HO-1), we studied iron distribution and pathology in HO-1(Hmox1)(−/−) mice. We found that resident splenic and liver macrophages were mostly absent in HO-1(−/−) mice....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3031391/ https://ncbi.nlm.nih.gov/pubmed/20844238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272138 |
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