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Dysfunction of the heme recycling system in heme oxygenase 1–deficient mice: effects on macrophage viability and tissue iron distribution

To better understand the tissue iron overload and anemia previously reported in a human patient and mice that lack heme oxygenase-1 (HO-1), we studied iron distribution and pathology in HO-1(Hmox1)(−/−) mice. We found that resident splenic and liver macrophages were mostly absent in HO-1(−/−) mice....

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Bibliografiske detaljer
Main Authors: Kovtunovych, Gennadiy, Eckhaus, Michael A., Ghosh, Manik C., Ollivierre-Wilson, Hayden, Rouault, Tracey A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3031391/
https://ncbi.nlm.nih.gov/pubmed/20844238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-272138
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