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Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress

Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroi...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Zhang, De-Liang, Ghosh, Manik C., Ollivierre, Hayden, Li, Yan, Rouault, Tracey A.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236465/
https://ncbi.nlm.nih.gov/pubmed/30213870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-842997
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