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Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress

Ferroportin (FPN), the only known vertebrate iron exporter, transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues and cells in vivo. Most of the circulating iron is consumed by erythroid cells to synthesize hemoglobin. Here we found that erythroi...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Zhang, De-Liang, Ghosh, Manik C., Ollivierre, Hayden, Li, Yan, Rouault, Tracey A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236465/
https://ncbi.nlm.nih.gov/pubmed/30213870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-04-842997
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