Therapeutic inhibition of HIF-2α reverses polycythemia and pulmonary hypertension in murine models of human diseases

Polycythemia and pulmonary hypertension are 2 human diseases for which better therapies are needed. Upregulation of hypoxia-inducible factor-2α (HIF-2α) and its target genes, erythropoietin (EPO) and endothelin-1, causes polycythemia and pulmonary hypertension in patients with Chuvash polycythemia w...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Ghosh, Manik C., Zhang, De-Liang, Ollivierre, Wade H., Noguchi, Audrey, Springer, Danielle A., Linehan, W. Marston, Rouault, Tracey A.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2021
Sujets:
Red Cells, Iron, and Erythropoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8109019/
https://ncbi.nlm.nih.gov/pubmed/33512384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020009138
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