Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2

ABCG2 is a potential biomarker causing multidrug resistance (MDR) in Non-Small Cell Lung Cancer (NSCLC). We conducted this study to investigate whether Icotinib, a small-molecule inhibitor of EGFR tyrosine kinase, could interact with ABCG2 transporter in NSCLC. Our results showed that Icotinib rever...

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Hlavní autoři: Wang, De-Shen, Patel, Atish, Shukla, Suneet, Zhang, Yun-Kai, Wang, Yi-Jun, Kathawala, Rishil J., Robey, Robert W., Zhang, Li, Yang, Dong-Hua, Talele, Tanaji T., Bates, Susan E., Ambudkar, Suresh V., Xu, Rui-Hua, Chen, Zhe-Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147343/
https://ncbi.nlm.nih.gov/pubmed/24980828
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