Masitinib antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance

In this in vitro study, we determined whether masitinib could reverse multidrug resistance (MDR) in cells overexpressing the ATP binding cassette subfamily G member 2 (ABCG2) transporter. Masitinib (1.25 and 2.5 μM) significantly decreases the resistance to mitoxantrone (MX), SN38 and doxorubicin in...

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Autori principali: KATHAWALA, RISHIL J., CHEN, JUN-JIANG, ZHANG, YUN-KAI, WANG, YI-JUN, PATEL, ATISH, WANG, DE-SHEN, TALELE, TANAJI T., ASHBY, CHARLES R., CHEN, ZHE-SHENG
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027943/
https://ncbi.nlm.nih.gov/pubmed/24626598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2341
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