Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1

Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP binding cassette (ABC) transporters. Som...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wang, Yi-Jun, Kathawala, Rishil J., Zhang, Yun-Kai, Patel, Atish, Kumar, Priyank, Shukla, Suneet, Fung, King Leung, Ambudkar, Suresh V., Talele, Tanaji T., Chen, Zhe-Sheng
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2014
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133117/
https://ncbi.nlm.nih.gov/pubmed/24937702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.06.006
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