Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1

Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP binding cassette (ABC) transporters. Som...

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Détails bibliographiques
Auteurs principaux: Wang, Yi-Jun, Kathawala, Rishil J., Zhang, Yun-Kai, Patel, Atish, Kumar, Priyank, Shukla, Suneet, Fung, King Leung, Ambudkar, Suresh V., Talele, Tanaji T., Chen, Zhe-Sheng
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133117/
https://ncbi.nlm.nih.gov/pubmed/24937702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.06.006
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