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Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Multidrug resistance (MDR) attenuates the chemotherapy efficacy and increases the probability of cancer recurrence. The accelerated drug efflux mediated by ATP-binding cassette (ABC) transporters is one of the major MDR mechanisms. This study investigated if TTT-28, a newly synthesized thiazole-vali...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Wang, Yi-Jun, Patel, Bhargav A., Anreddy, Nagaraju, Zhang, Yun-Kai, Zhang, Guan-Nan, Alqahtani, Saeed, Singh, Satyakam, Shukla, Suneet, Kaddoumi, Amal, Ambudkar, Suresh V., Talele, Tanaji T., Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299601/
https://ncbi.nlm.nih.gov/pubmed/28181548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42106
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