Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1

Multidrug resistance (MDR) attenuates the chemotherapy efficacy and increases the probability of cancer recurrence. The accelerated drug efflux mediated by ATP-binding cassette (ABC) transporters is one of the major MDR mechanisms. This study investigated if TTT-28, a newly synthesized thiazole-vali...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Wang, Yi-Jun, Patel, Bhargav A., Anreddy, Nagaraju, Zhang, Yun-Kai, Zhang, Guan-Nan, Alqahtani, Saeed, Singh, Satyakam, Shukla, Suneet, Kaddoumi, Amal, Ambudkar, Suresh V., Talele, Tanaji T., Chen, Zhe-Sheng
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299601/
https://ncbi.nlm.nih.gov/pubmed/28181548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42106
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