Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance

Sildenafil is a potent and selective inhibitor of the type 5 cGMP-specific phosphodiesterase that is used clinically to treat erectile dysfunction and pulmonary arterial hypertension. Here we report that sildenafil has differential effects on cell surface ABC transporters such as ABCB1, ABCC1 and AB...

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Detalhes bibliográficos
Main Authors: Shi, Zhi, Tiwari, Amit K, Shukla, Suneet, Robey, Robert W., Singh, Satyakam, Kim, In-Wha, Bates, Susan E., Peng, Xingxiang, Abraham, Ioana, Ambudkar, Suresh V., Talele, Tanaji T., Fu, Li-Wu, Chen, Zhe-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078184/
https://ncbi.nlm.nih.gov/pubmed/21402712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3820
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