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Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance

Sildenafil is a potent and selective inhibitor of the type 5 cGMP-specific phosphodiesterase that is used clinically to treat erectile dysfunction and pulmonary arterial hypertension. Here we report that sildenafil has differential effects on cell surface ABC transporters such as ABCB1, ABCC1 and AB...

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Main Authors:	Shi, Zhi, Tiwari, Amit K, Shukla, Suneet, Robey, Robert W., Singh, Satyakam, Kim, In-Wha, Bates, Susan E., Peng, Xingxiang, Abraham, Ioana, Ambudkar, Suresh V., Talele, Tanaji T., Fu, Li-Wu, Chen, Zhe-Sheng
Format:	Artigo
Jezik:	Inglês
Izdano:	2011
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3078184/ https://ncbi.nlm.nih.gov/pubmed/21402712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3820
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Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance

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