Inhibiting the Function of ABCB1 and ABCG2 by the EGFR Tyrosine Kinase Inhibitor AG1478

The tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyquinazoline (AG1478) is a potent and specific EGFR tyrosine kinase inhibitor (TKI); its promising pre-clinical results have led to clinical trials. Overexpression of ATP-binding cassette (ABC) transporters such as ABCB1, ABCC1 and ABCG2 is one of the m...

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Main Authors: Shi, Zhi, Tiwari, Amit K, Shukla, Suneet, Robey, Robert W., Kim, In-Wha, Parmar, Smitaben, Bates, Susan E., Si, Qiu-Sheng, Goldblatt, Curtis S., Abraham, Ioana, Fu, Li-Wu, Ambudkar, Suresh V., Chen, Zhe-Sheng
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843910/
https://ncbi.nlm.nih.gov/pubmed/19059384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2008.11.007
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