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New Inhibitors of ABCG2 Identified by High-throughput Screening

In order to identify novel inhibitors of the ATP-binding cassette transporter ABCG2, a high throughput assay measuring accumulation of the ABCG2 substrate pheophorbide a in ABCG2 overexpressing NCI-H460 MX20 cells was used to screen libraries of compounds. Out of a library of 7325 natural products a...

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Main Authors: Henrich, Curtis J., Robey, Robert W., Bokesch, Heidi R., Bates, Susan E., Shukla, Suneet, Ambudkar, Suresh V., Dean, Michael, McMahon, James B.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760480/
https://ncbi.nlm.nih.gov/pubmed/18089721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-07-0352
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