The Pim kinase inhibitor SGI-1776 decreases cell surface expression of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and drug transport by Pim-1-dependent and -independent mechanisms

Overexpression of the ATP-binding cassette (ABC) drug efflux proteins P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) on malignant cells is associated with inferior chemotherapy outcomes. Both, ABCB1 and ABCG2, are substrates of the serine/threonine kinase Pim-1; Pim-1 knockdown...

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Detalhes bibliográficos
Main Authors: Natarajan, Karthika, Bhullar, Jasjeet, Shukla, Suneet, Burcu, Mehmet, Chen, Zhe-Sheng, Ambudkar, Suresh V., Baer, Maria R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821043/
https://ncbi.nlm.nih.gov/pubmed/23261525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2012.12.006
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