Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during which the free drug concentrations in plasma are...

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Autors principals: Lakshminarayana, Suresh B., Boshoff, Helena I. M., Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Barry, Clifton E., Ho, Paul C., Manjunatha, Ujjini H.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4139342/
https://ncbi.nlm.nih.gov/pubmed/25141257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0105222
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