Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties

[Image: see text] Largazole is a potent and class I-selective histone deacetylase (HDAC) inhibitor purified from marine cyanobacteria and was demonstrated to possess antitumor activity. Largazole employs a unique prodrug strategy, via a thioester moiety, to liberate the bioactive species largazole t...

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Autori principali: Salvador, Lilibeth A., Park, Heekwang, Al-Awadhi, Fatma H., Liu, Yanxia, Kim, Bumki, Zeller, Sabrina L., Chen, Qi-Yin, Hong, Jiyong, Luesch, Hendrik
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137384/
https://ncbi.nlm.nih.gov/pubmed/25147612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500170r
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