Φορτώνει......
Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties
[Image: see text] Largazole is a potent and class I-selective histone deacetylase (HDAC) inhibitor purified from marine cyanobacteria and was demonstrated to possess antitumor activity. Largazole employs a unique prodrug strategy, via a thioester moiety, to liberate the bioactive species largazole t...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
|---|---|
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Chemical
Society
2014
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| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4137384/ https://ncbi.nlm.nih.gov/pubmed/25147612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500170r |
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