Constrained Bithiazoles: Small Molecule Correctors of Defective ΔF508–CFTR Protein Trafficking

[Image: see text] Conformationally constrained bithiazoles were previously found to have improved efficacy over nonconstrained bithiazoles for correction of defective cellular processing of the ΔF508 mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. In this study, two sets o...

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Hauptverfasser: Coffman, Keith C., Nguyen, Huy H., Phuan, Puay-Wah, Hudson, Brandi M., Yu, Gui J., Bagdasarian, Alex L., Montgomery, Deanna, Lodewyk, Michael W., Yang, Baoxue, Yoo, Choong L., Verkman, A. S., Tantillo, Dean J., Kurth, Mark J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2014
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136667/
https://ncbi.nlm.nih.gov/pubmed/25061695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5007885
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