RhoB Promotes γH2AX Dephosphorylation and DNA Double-Strand Break Repair

Unlike other Rho GTPases, RhoB is rapidly induced by DNA damage, and its expression level decreases during cancer progression. Because inefficient repair of DNA double-strand breaks (DSBs) can lead to cancer, we investigated whether camptothecin, an anticancer drug that produces DSBs, induces RhoB e...

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Main Authors: Mamouni, Kenza, Cristini, Agnese, Guirouilh-Barbat, Josée, Monferran, Sylvie, Lemarié, Anthony, Faye, Jean-Charles, Lopez, Bernard S., Favre, Gilles, Sordet, Olivier
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135599/
https://ncbi.nlm.nih.gov/pubmed/24912678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01525-13
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