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Transcription-dependent DNA double-strand breaks and human disease
Accumulation of DNA damage in resting cells is an emerging cause of human disease. We identified a mechanism of DNA double-strand break (DSB) formation in non-replicating cells, which strictly depends on transcription. These transcriptional DSBs arise from the twinned processing of R-loops and topoi...
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| Publié dans: | Mol Cell Oncol |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2020
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7051148/ https://ncbi.nlm.nih.gov/pubmed/32158914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1691905 |
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