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DNA double-strand breaks and ATM activation by transcription-blocking DNA lesions
Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA double-strand break (DSB) response. We recently showed that transcription-blocking topoisomerase I cleavage complexes (TOP1cc) produce DSBs related to R-loop form...
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| Publicado en: | Cell Cycle |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7289056/ https://ncbi.nlm.nih.gov/pubmed/20023421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.2.10506 |
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