Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks

Ataxia telangiectasia mutated (ATM), the deficiency of which causes a severe neurodegenerative disease, is a crucial mediator for the DNA damage response (DDR). As neurons have high rates of transcription that require topoisomerase I (TOP1), we investigated whether TOP1 cleavage complexes (TOP1cc)—w...

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Autori principali: Sordet, Olivier, Redon, Christophe E, Guirouilh-Barbat, Josée, Smith, Susan, Solier, Stéphanie, Douarre, Céline, Conti, Chiara, Nakamura, Asako J, Das, Benu B, Nicolas, Estelle, Kohn, Kurt W, Bonner, William M, Pommier, Yves
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2009
Soggetti:
Scientific Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726680/
https://ncbi.nlm.nih.gov/pubmed/19557000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2009.97
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