Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Although accumulation of DNA damage and genomic instability in resting cells can cause neurodegenerative disorders, our understanding of how transcription produces DNA double-strand breaks (DSBs) is limited. Transcription-blocking topoisomerase I cleavage complexes (TOP1ccs) are frequent events that...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Cristini, Agnese, Ricci, Giulia, Britton, Sébastien, Salimbeni, Simona, Huang, Shar-yin Naomi, Marinello, Jessica, Calsou, Patrick, Pommier, Yves, Favre, Gilles, Capranico, Giovanni, Gromak, Natalia, Sordet, Olivier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8274950/
https://ncbi.nlm.nih.gov/pubmed/31533039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.041
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