Dynamic Effects of Topoisomerase I Inhibition on R-Loops and Short Transcripts at Active Promoters

Topoisomerase I-DNA-cleavage complexes (Top1cc) stabilized by camptothecin (CPT) have specific effects at transcriptional levels. We recently reported that Top1cc increase antisense transcript (aRNAs) levels at divergent CpG-island promoters and, transiently, DNA/RNA hybrids (R-loop) in nuclear and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Marinello, Jessica, Bertoncini, Stefania, Aloisi, Iris, Cristini, Agnese, Malagoli Tagliazucchi, Guidantonio, Forcato, Mattia, Sordet, Olivier, Capranico, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718701/
https://ncbi.nlm.nih.gov/pubmed/26784695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147053
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