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Anthracyclines as Topoisomerase II Poisons: From Early Studies to New Perspectives
Mammalian DNA topoisomerases II are targets of anticancer anthracyclines that act by stabilizing enzyme-DNA complexes wherein DNA strands are cut and covalently linked to the protein. This molecular mechanism is the molecular basis of anthracycline anticancer activity as well as the toxic effects su...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2018-11-01
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| Colecção: | International Journal of Molecular Sciences |
| Assuntos: | |
| Acesso em linha: | https://www.mdpi.com/1422-0067/19/11/3480 |
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