Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee

Anticancer drugs are combined in an effort to treat a heterogeneous tumor or to maximize the pharmacodynamic effect. The development of combination regimens, while desirable, poses unique challenges. These include the selection of agents for combination therapy that may lead to improved efficacy whi...

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Detalhes bibliográficos
Main Authors: Paller, Channing J., Bradbury, Penelope A., Ivy, S. Percy, Seymour, Lesley, LoRusso, Patricia M., Baker, Laurence, Rubinstein, Larry, Huang, Erich, Collyar, Deborah, Groshen, Susan, Reeves, Steven, Ellis, Lee M., Sargent, Daniel J., Rosner, Gary L., LeBlanc, Michael L., Ratain, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135521/
https://ncbi.nlm.nih.gov/pubmed/25125258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0521
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