Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee

Anticancer drugs are combined in an effort to treat a heterogeneous tumor or to maximize the pharmacodynamic effect. The development of combination regimens, while desirable, poses unique challenges. These include the selection of agents for combination therapy that may lead to improved efficacy whi...

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Autors principals: Paller, Channing J., Bradbury, Penelope A., Ivy, S. Percy, Seymour, Lesley, LoRusso, Patricia M., Baker, Laurence, Rubinstein, Larry, Huang, Erich, Collyar, Deborah, Groshen, Susan, Reeves, Steven, Ellis, Lee M., Sargent, Daniel J., Rosner, Gary L., LeBlanc, Michael L., Ratain, Mark J.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135521/
https://ncbi.nlm.nih.gov/pubmed/25125258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0521
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