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The Design of Phase II Clinical Trials Testing Cancer Therapeutics: Consensus Recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee

The optimal design of phase II studies continues to be the subject of vigorous debate, especially with regards to studies of newer molecularly targeted agents. The observations that many new therapeutics ‘fail’ in definitive phase III studies, coupled with the numbers of new agents to be tested as w...

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Dettagli Bibliografici
Autori principali: Seymour, Lesley, Ivy, S. Percy, Sargent, Daniel, Spriggs, David, Baker, Laurence, Rubinstein, Larry, Ratain, Mark J, Le Blanc, Michael, Stewart, David, Crowley, John, Groshen, Susan, Humphrey, Jeffrey S, West, Pamela, Berry, Donald
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840069/
https://ncbi.nlm.nih.gov/pubmed/20215557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3287
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