The Design of Phase II Clinical Trials Testing Cancer Therapeutics: Consensus Recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee

The optimal design of phase II studies continues to be the subject of vigorous debate, especially with regards to studies of newer molecularly targeted agents. The observations that many new therapeutics ‘fail’ in definitive phase III studies, coupled with the numbers of new agents to be tested as w...

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Detalhes bibliográficos
Main Authors: Seymour, Lesley, Ivy, S. Percy, Sargent, Daniel, Spriggs, David, Baker, Laurence, Rubinstein, Larry, Ratain, Mark J, Le Blanc, Michael, Stewart, David, Crowley, John, Groshen, Susan, Humphrey, Jeffrey S, West, Pamela, Berry, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840069/
https://ncbi.nlm.nih.gov/pubmed/20215557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3287
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