The Design of Phase II Clinical Trials Testing Cancer Therapeutics: Consensus Recommendations from the Clinical Trial Design Task Force of the National Cancer Institute Investigational Drug Steering Committee

The optimal design of phase II studies continues to be the subject of vigorous debate, especially with regards to studies of newer molecularly targeted agents. The observations that many new therapeutics ‘fail’ in definitive phase III studies, coupled with the numbers of new agents to be tested as w...

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Bibliografiske detaljer
Main Authors: Seymour, Lesley, Ivy, S. Percy, Sargent, Daniel, Spriggs, David, Baker, Laurence, Rubinstein, Larry, Ratain, Mark J, Le Blanc, Michael, Stewart, David, Crowley, John, Groshen, Susan, Humphrey, Jeffrey S, West, Pamela, Berry, Donald
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840069/
https://ncbi.nlm.nih.gov/pubmed/20215557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3287
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