Design of Phase I Combination Trials: Recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee

Anticancer drugs are combined in an effort to treat a heterogeneous tumor or to maximize the pharmacodynamic effect. The development of combination regimens, while desirable, poses unique challenges. These include the selection of agents for combination therapy that may lead to improved efficacy whi...

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Détails bibliographiques
Auteurs principaux: Paller, Channing J., Bradbury, Penelope A., Ivy, S. Percy, Seymour, Lesley, LoRusso, Patricia M., Baker, Laurence, Rubinstein, Larry, Huang, Erich, Collyar, Deborah, Groshen, Susan, Reeves, Steven, Ellis, Lee M., Sargent, Daniel J., Rosner, Gary L., LeBlanc, Michael L., Ratain, Mark J.
Format: Artigo
Langue:Inglês
Publié: 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135521/
https://ncbi.nlm.nih.gov/pubmed/25125258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0521
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