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The Rationale for Targeting the NAD/NADH Cofactor Binding Site of Parasitic S-Adenosyl-L-homocysteine Hydrolase for the Design of Anti-parasitic Drugs

Trypanosomal S-adenoyl-L-homocysteine hydrolase (Tc-SAHH), considered as a target for treatment of Chagas disease, has the same catalytic mechanism as human SAHH (Hs-SAHH) and both enzymes have very similar X-ray structures. Efforts toward the design of selective inhibitors against Tc-SAHH targeting...

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Библиографические подробности
Главные авторы: Cai, Sumin, Li, Qing-Shan, Fang, Jianwen, Borchardt, Ronald T., Kuczera, Krzysztof, Middaugh, C. Russell, Schowen, Richard L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128003/
https://ncbi.nlm.nih.gov/pubmed/20183598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15257770903051031
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