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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. The role of lysyl and tyrosyl residues of the C-terminal extension
Based on the available X-ray structures of S-adenosylhomocysteine hydrolases (SAHHs), free energy simulations employing the MM-GBSA approach were applied to predict residues important to the differential cofactor binding properties of human and trypanosomal SAHHs (Hs-SAHH and Tc-SAHH), within 5 Å of...
Tallennettuna:
Päätekijät: | , , , , , , |
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Aineistotyyppi: | Artigo |
Kieli: | Inglês |
Julkaistu: |
2010
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Aiheet: | |
Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2962933/ https://ncbi.nlm.nih.gov/pubmed/20687591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1007595 |
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