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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 3. The role of lysyl and tyrosyl residues of the C-terminal extension

Based on the available X-ray structures of S-adenosylhomocysteine hydrolases (SAHHs), free energy simulations employing the MM-GBSA approach were applied to predict residues important to the differential cofactor binding properties of human and trypanosomal SAHHs (Hs-SAHH and Tc-SAHH), within 5 Å of...

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Dettagli Bibliografici
Autori principali: Cai, Sumin, Fang, Jianwen, Li, Qing-Shan, Borchardt, Ronald T., Kuczera, Krzysztof, Middaugh, C. Russell, Schowen, Richard L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962933/
https://ncbi.nlm.nih.gov/pubmed/20687591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi1007595
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