S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic

S-adenosyl-L-homocysteine (SAH) hydrolases (SAHases) are involved in the regulation of methylation reactions in many organisms and are thus crucial for numerous cellular functions. Consequently, their dysregulation is associated with severe health problems. The SAHase-catalyzed reaction is reversibl...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Kailing, Lyn L., Bertinetti, Daniela, Paul, Caroline E., Manszewski, Tomasz, Jaskolski, Mariusz, Herberg, Friedrich W., Pavlidis, Ioannis V.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2018
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871694/
https://ncbi.nlm.nih.gov/pubmed/29619018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2018.00505
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