Poisoning of Mitochondrial Topoisomerase I by Lamellarin D

Lamellarin D (Lam-D) is a hexacyclic pyrole alkaloid isolated from marine invertebrates, whose biologic properties have been attributed to mitochondrial targeting. Mitochondria contain their own DNA (mtDNA), and the only specific mitochondrial topoisomerase in vertebrates is mitochondrial topoisomer...

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Hauptverfasser: Khiati, Salim, Seol, Yeonee, Agama, Keli, Rosa, Ilaria Dalla, Agrawal, Surbhi, Fesen, Katherine, Zhang, Hongliang, Neuman, Keir C., Pommier, Yves
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127927/
https://ncbi.nlm.nih.gov/pubmed/24890608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092833
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