Poisoning of Mitochondrial Topoisomerase I by Lamellarin D

Lamellarin D (Lam-D) is a hexacyclic pyrole alkaloid isolated from marine invertebrates, whose biologic properties have been attributed to mitochondrial targeting. Mitochondria contain their own DNA (mtDNA), and the only specific mitochondrial topoisomerase in vertebrates is mitochondrial topoisomer...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Khiati, Salim, Seol, Yeonee, Agama, Keli, Rosa, Ilaria Dalla, Agrawal, Surbhi, Fesen, Katherine, Zhang, Hongliang, Neuman, Keir C., Pommier, Yves
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Pharmacology and Experimental Therapeutics 2014
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4127927/
https://ncbi.nlm.nih.gov/pubmed/24890608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.092833
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