Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia

ZAP-70 methylation 223 nucleotides downstream of transcription start (CpG+223) predicts outcome in chronic lymphocytic leukemia (CLL), but its impact relative to CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain. Additionally, standardizing ZAP-70 ex...

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Bibliografiske detaljer
Main Authors: Claus, Rainer, Lucas, David M., Ruppert, Amy S., Williams, Katie E., Weng, Daniel, Patterson, Kara, Zucknick, Manuela, Oakes, Christopher C., Rassenti, Laura Z., Greaves, Andrew W., Geyer, Susan, Wierda, William G., Brown, Jennifer R., Gribben, John G., Barrientos, Jacqueline C., Rai, Kanti R., Kay, Neil E., Kipps, Thomas J., Shields, Peter, Zhao, Weiqiang, Grever, Michael R., Plass, Christoph, Byrd, John C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2014
Fag:
Clinical Trials and Observations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125353/
https://ncbi.nlm.nih.gov/pubmed/24868078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555722
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