Validation of ZAP-70 methylation and its relative significance in predicting outcome in chronic lymphocytic leukemia

ZAP-70 methylation 223 nucleotides downstream of transcription start (CpG+223) predicts outcome in chronic lymphocytic leukemia (CLL), but its impact relative to CD38 and ZAP-70 expression or immunoglobulin heavy chain variable region (IGHV) status is uncertain. Additionally, standardizing ZAP-70 ex...

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Detalhes bibliográficos
Main Authors: Claus, Rainer, Lucas, David M., Ruppert, Amy S., Williams, Katie E., Weng, Daniel, Patterson, Kara, Zucknick, Manuela, Oakes, Christopher C., Rassenti, Laura Z., Greaves, Andrew W., Geyer, Susan, Wierda, William G., Brown, Jennifer R., Gribben, John G., Barrientos, Jacqueline C., Rai, Kanti R., Kay, Neil E., Kipps, Thomas J., Shields, Peter, Zhao, Weiqiang, Grever, Michael R., Plass, Christoph, Byrd, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4125353/
https://ncbi.nlm.nih.gov/pubmed/24868078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-02-555722
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